Headquarters Location: South San Francisco, CA

Candidate Location: Hybrid

Travel Required: 5%

Reports To: Scientist II, Protein Sciences

Position Type: Exempt

About CytomX Therapeutics

CytomX Therapeutics, Inc. is committed to changing the treatment of cancer with our novel Probody® therapeutic platform. Our commitment to transforming lives with safer, more effective therapies is driven by our curiosity and passion for innovation and our belief that by acting with integrity in an honest, respectful, ethical manner, we have the power to change lives. Our workplace embodies collaboration, open communication, celebrating our successes, and holding each other to the highest possible standards. CytomX has a broad pipeline, which comprises seven therapeutic candidates across multiple treatment modalities including antibody-drug conjugates (“ADCs”), T-cell engaging bispecific antibodies (“TCBs”), and immune modulators such as cytokines and checkpoint inhibitors (“CPIs”). Learn more at www.cytomx.com.

Position Summary

We seek a highly motivated individual to support the protein purification and analytical method development needs for all the discovery programs at CytomX. The successful candidate will work as an SRA in the Protein Sciences Department and contribute to the lead selection process by implementation of parallel purification and developability assessment of Probodies, bispecific, and cytokines.

Professional Responsibilities

• Develop parallel purification processes for antibodies, Probodies, Bispecifics and cytokines.
• Support the protein purification workflow to meet the needs from Protein Engineering, Process Sciences, and biology groups.
• Develop purification strategies for various bispecific formats and cytokines
• Solve protein purification problems based on scientific principles, current technologies, and personal experience
• Develop analytical and biophysical methods to characterize Probodies, Probody drug conjugates, and bispecifics to support Discovery programs
• Organize data and communicate results in internal and external scientific meetings

Minimum Qualifications

• MS in Biochemistry with 4+ years of experience in the biotechnology or biopharma industry OR BS in Biochemistry with 6+ years of experience in the biotechnology or biopharma industry
• Expertise in large and small-scale protein purification using AKTA systems and Tecan liquid handler system is required.
• Experience in developing ELISA based potency assays is required
• Experience in developing analytical methods to characterize antibodies is required.
• Experience in managing the protein purification workflow is required

Preferred Qualifications

• Should be well versed in protein characterization assays such as concentration, endotoxin measurement, SDS-PAGE, CE-SDS, SEC-HPLC, RP-HPLC, IEF, and HIC
• Familiarity with polyclonal and monoclonal anti-Id generation process is desired
• Hands-on experience in operating Agilent/Waters/Thermo HPLC or UPLC instruments, Maurice iCIEF and CE-SDS systems is desired
• Hands-on experience in operating the mass spec instruments is preferred
• Energetic, resourceful self-starter with high integrity
• Team player comfortable in fast-moving, dynamic environments
• Intellectually curious, enthusiastic, creative
• Adaptable and resilient with a problem-solving orientation
• Innovative and flexible
• Demonstrate a commitment to CytomX values of Integrity, Commitment, Creativity, Teamwork, Accountability, and Fun

Salary and Benefits

• The expected salary range for this role based on the primary location for this position in California is $107,000 - $128,000 per year. Offer amounts are determined by factors such as experience, qualifications, geographic location, and other job-related factors permitted by law.
• A comprehensive list of total reward offerings that may impact total compensation can be found on our website.

Conditions of Employment

• Background investigations are required for all positions at CytomX, consistent with applicable law.

CytomX’s Commitment to Diversity, Equity, Inclusion, and Belonging (DEIB)

CytomX believes that DEIB helps drive our success, and we encourage candidates from all identities, backgrounds, and abilities to apply. We are an equal opportunity employer committed to building an inclusive, innovative work environment with employees who reflect our values and ultimately, serve our patients. Therefore, in all aspects of the employment process, we provide employment opportunities to all qualified applicants without regard to race, color, religion, sex, disability, age, sexual orientation, gender identity or expression, pregnancy, medical condition related to pregnancy, creed, ancestry, national origin, marital status, genetic information, or military status, or any other protected status in accordance with applicable law.

Further, we are committed to the full inclusion of all qualified individuals. As part of this commitment, we (and the agencies we work with) will assist individuals who have a disability with any reasonable accommodation requests related to employment, including completing the application process, interviewing, completing any pre-employment testing, participating in the employee selection process, and/or to perform essential job functions where the requested accommodation does not impose an undue hardship. If you have a disability and require reasonable accommodation, or need other assistance in applying for or interviewing for this position, please direct your inquiries to Human Resources, at hr@cytomx.com.

Notice to Recruiters/Staffing Agencies

Recruiters and staffing agencies should not contact CytomX Therapeutics through this page. We require that all Recruitment Vendors (e.g., search firms, recruitment agencies, and staffing companies) have a fully executed, formal written agreement on file with CytomX prior to submitting candidates. Any resumes submitted through the website or directly by Recruitment Vendors will be considered unsolicited. Unsolicited vendor submissions do not constitute any actual or implied contract with CytomX, and CytomX will not be responsible for any purported fees. For more information, please contact our HR team at hr@cytomx.com.

Please review our Applicant Personal Information Processing Notice to understand what types of personal information we collect from job applicants and why we process such information.