Job description

Our laboratory studies ovarian cancer, focusing on mechanisms of cancer initiation, progression and drug resistance. We are seeking a highly motivated postdoctoral fellow to join our team. In this position, you will participate in the analysis of scRNAseq and multi-plex spatial imaging data from pre- and post- treatment biopsies in order to identify proteins to target for therapeutic interventions to prevent cancer relapse. In addition, you will also be involved in a project involving testing nanoparticle formulations of combination drug therapies and validating the treatment responses in ovarian cancer patient-derived xenograft (PDX) models. You will perform correlative studies for the development and evaluation of targeted therapy combinations in ovarian cancer cell lines, patient-derived xenograft models, organoids and primary tumor samples. In addition, you will investigate the genetic and proteomic markers that correlate with efficacy to identify putative biomarkers and candidate mechanisms for the differential drug responses. This position provides an excellent opportunity to gain experience in scRNAseq and multi-plex data analysis, drug discovery and translational studies.

Technical Duties and Responsibilities

• Perform cell culture of patient-derived cancer cell lines using aseptic technique
• Perform drug treatment and generation of dose-response curves in patient-derived cells
• Perform various molecular analyses to identify mutations, translocations, and copy number alterations in pre- and post-treatment samples
• Characterize the proteomic adaptive responses in pre- and post-treatment samples
• Analyze clinical samples using proteomics and in situ imaging approaches
• Maintain tumor cell lines, tumor organoid cultures and patient-derived xenograft models
• Generate figures from these analyses for presentations and publications
• Communicate regularly with project collaborators on analysis progress and outcomes
• Perform flow cytometry, high-content imaging and other molecular bench work

Knowledge, skills and abilities required

• PhD in tumor biology, pharmacology, biochemistry or similar
• 0-3 years post-degree experience (PhD students in the last year of their thesis work are eligible to apply)
• Experience or demonstrated interest in tumor biology
• Strong record of scientific achievement: publications, conference presentations, etc.
• Extensive hands-on wet-lab experience
• Excellent analytical, communication and organizational skills
• Ability to work independently as well as with interdisciplinary teams
• Must be willing to make a minimum 2-year commitment.

Special Working conditions

None.

Additional Information:

The University requires all Harvard community members to be fully vaccinated against COVID-19 and remain up to date with COVID-19 vaccine boosters, as detailed in Harvard’s Vaccine & Booster Requirements. Individuals may claim exemption from the vaccine requirement for medical or religious reasons. More information regarding the University’s COVID vaccination requirement, exemptions, and verification of vaccination status may be found at the University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/.

Please note that we are currently conducting a majority of interviews and onboarding remotely and virtually. We appreciate your understanding.

Commitment to Equity, Diversity, Inclusion, and Belonging

We are committed to cultivating an inclusive workplace culture of faculty, staff, and students with diverse backgrounds, styles, abilities, and motivations. We appreciate and leverage the capabilities, insights, and ideas of all individuals. Harvard Medical School Mission and Community Values: https://hms.harvard.edu/about-hms/campus-culture/mission-community-values-diversity-statement

EEO Statement

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability status, protected veteran status, gender identity, sexual orientation, pregnancy and pregnancy-related conditions, or any other characteristic protected by law.

Job Type: Full-time

Pay: From $60,000.00 per year

Schedule:

• Monday to Friday
• Weekend availability

COVID-19 considerations:
Harvard University’s “COVID-19 Vaccine Information” webpage: http://www.harvard.edu/coronavirus/covid-19-vaccine-information/

Application Question(s):

• Please provide the contact information for 3 references.

Education:

• Doctorate (Required)

Experience:

• Molecular biology: 4 years (Required)

Work Location: In person

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