Our expanding In Vivo Pharmacology group in South San Francisco, CA has an opening for a motivated tumor biologist who is dedicated to the discovery and development of innovative therapeutics, both small molecule and biologics, with a focus on immuno-oncology. The Scientist II/Senior Scientist II will perform tumor efficacy and PK/PD studies and provide pharmacology support to innovative cancer drug development. The scientist will work collaboratively in a project team setting with biology, medicinal chemistry, biologics, and DMPK scientists, formulating and executing efficient in vivo structure activity relationship strategy and advancing oncology programs to clinical development.

Key Accountabilities/Core Job Responsibilities:

• Design, execute and optimize efficacy/PK/PD studies utilizing tumor models in both immunocompetent and immunocompromised mice.
• Understand and adhere to IACUC protocols regarding animal welfare and handling.
• Conduct tissue culture and ex vivo assays such as multi-color FACS, MSD, WES and Luminex.
• Data analyses and presentation of study results, and work across discovery teams to integrate efficient workflows for cross-functional collaborations.
• Commitment to scientific rigor, high data quality and careful documentation.

• Scientist II: MS with 5+ years of experience, or BS with 7+ years of experience with a degree in cancer biology, immunology, pharmacology, or a related with extensive hands-on skills of in vivo tumor model execution.

• Senior Scientist I: PhD with 1-3 years of experience, MS with 8+ years, or BS with 10+ years with a degree in cancer biology, immunology, pharmacology, or a related with extensive hands-on skills of in vivo tumor model execution; preferably in a pharmaceutical or biotech industry setting.

• Proficient hands-on experience with in vivo tumor model development, including tissue harvesting (blood, spleen, lymph node, etc.), tumor inoculation and dosing via different routes/sites (SC, IP, PO, IV), and tumor volume measurement.
• Technical experience in cell culture, cell cryopreservation, and tissue processing.
• Knowledge of PK/PD relationships, flow cytometry, and other standard molecular and cellular biology assays (MSD, ELISA, Wes, etc.) is an advantage.
• Must be proactive and able to manage multiple responsibilities, adapt to changing priorities and meet deadlines in a fast-paced environment.
• Excellent verbal and written communication skills and the willingness to work and build strong relationships with peers in a multidisciplinary team.
• Flexibility and motivation to learn techniques and accomplish goals outside those stated above.

AbbVie is an equal opportunity employer including disability/vets. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a disabled veteran, recently separated veteran, Armed Forces service medal veteran or active duty wartime or campaign badge veteran or a person’s relationship or association with a protected veteran, including spouses and other family members, or any other protected group status. We will take affirmative action to employ and advance in employment qualified minorities, women, individuals with a disability, disabled veterans, recently separated veterans, Armed Forces service medal veterans or active-duty wartime or campaign badge veterans. The Affirmative Action Plan is available for viewing in the Human Resources office during regular business hours.